Nateglinide Modified Release Dosage Form Using Elementary Osmotic Pump and Push Pull Osmotic Pump Methods: Formulation and in-vivo evaluation

Objective: The aim was to develop osmotic tablets of nateglinide by two methods namely elementary pump (EOP) and push-pull (PPOP) method for controlled drug release.
 Methods: were prepared the wet granulation evaluated various physicochemical parameters, in-vitro dissolution dissolution. optimised formulation obtained in both further characterised FTIR, stability studies pharmacokinetic studies.
 Results: In EOP coated tablet F14 showing highest release 98.82%. PPOP FF14 optimized with 99.97% also its granules having better flow property. Both characterized which showed no significant interaction accelerated indicated formulations stable 3months. in-vivo rabbits revealead Cmax (FF14) 469.67±0.034 ng/ml, marketed product 401.27±0.08 ng/ml. Tmax pure 6.0±0.07 h 1.5±0.04 h, respectively. AUC0-infinity higher ((2829.83±1.47 ng.h/ml) than suspension (1310.62±0.82 ng.h/ml). AUC0-t significantly that (p<0.05).
 Conclusion: A improvement profile bioavailability observed using method.